FORMULATION, DEVELOPMENT AND EVALUATION APPROACH FOR MUCOADHESIVE TABLETS

Gadekar Madhuri Rajendra*, Dr. Vijaya Barge and Dr. Ashok Bhosale

ABSTRACT

The present study has shown that Drug prepared tablets gave promising results in terms of mucoadhesive resistance and in vitro permeation of the dosage form. The present research was planned for the formulation and development of Drug hole-adhesive tablets with 2 factors, namely Moringa gum and Xanthan gum in 3 different levels. For the formulation of hole-adhesive tablets, MG and XG are used in 3 different levels with direct compressible lactose as a diluent. Fixed amount of ethyl Cellulose used as a support layer. The formulation variables include the nature and quantity of polymers and diluents with different physico-chemical properties, mucoadhesive resistance, swelling index studies, in vitro permeability studies and stability. Prestressing parameters such as rest angle, bulk density, shunt density, compressibility index and host ratio within the prescribed limits. The prepared oral adhesive tablets were evaluated for post-compression parameters such as hardness, weight variation, thickness, friability, and swelling index, uniformity of the drug content, surface pH, and mucoadhesive resistance. All prepared oral tablets were found to follow an abnormal non-Fickian release. The formulation was stable with respect to the content of the drug, permeation in vitro during the stability study period.

Keywords: Drug, mucoadhesive tablet, mucoadhesive resistance, Moringa gum and Xanthan gum.