EFFECT OF LURASIDONE ON POSITIVE SYMPTOMS IN SCHIZOPHRENIA PATIENTS IN RURAL SETTING IN INDIA: A LONGITUDANAL STUDY

Darshan Yallappa Jotibannad Dr. Gaurav Uppal*, Dr. Aseem Garg, Dr. P. D. Garg and Dr. Shiny Dehal

ABSTRACT

Background and objectives: New antipsychotics have modified the course of schizophrenia. Not many medications have shown improvement in negative symptoms, and psychological shortages, compounded by unbearable results. Lurasidone is a moderately new participant in the field of schizophrenia in the Indian setting. This investigation assessed the general viability of Lurasidone across positive symptoms of schizophrenia. Methods: This is a longitudinal observational investigation. PANSS was administered at the time of admission, first month and following 3 months. An aggregate of 57 patients, analyzed utilizing ICD-10 standards, were selected, from the psychiatry OPD of MVJ Medical College and Research Hospital. 7 patients left because of grievousness. Measurable examination of the information was done on the SPSS (Statistical Package for Social Sciences Software). Utilizing suitable measurable techniques, dimensional examinations were made utilizing the focal propensities like the Mean with Standard Deviations for Lurasidone. T- test was applied for finding out the significance of ‘p’ values where appropriate. Results: In positive scale of PANSS, mean decrease of positive score toward the finish of multi week was 6.13, toward the finish of 3 months the mean positive score was 10.9.The current investigation showed that Lurasidone has impact on certain manifestations of schizophrenia at week 4 and better adequacy at week 12. By and large outcomes show better reaction to positive symptoms. Anyway a more drawn out follow up would help us study the impact of Lurasidone on the course of schizophrenia.

Keywords: Lurasidone; efficacy; Indian population; schizophrenia; positive symptoms.