RESEARCH PROGRESS IN CHRONIC LYMPHOCYTIC LEUKEMIA

Iftikhar Ali, Yanting Jiang, Wu fan and Shangqin Liu*

ABSTRACT

Cancer is an uncontrolled division of cell occurs due to genetic alterations and mutation. Chronic lymphocytic leukemia is the heterogeneous lymphocytic malignancy worldwide that leads to death. The advancement of genetic analysis techniques and the identification of suitable biomarkers show significant differences in the treatment period. In this paper will discuss the microRNA that is small Non-coding RNAs and is involved in CLL beginning, development, and resistance to therapy and also will explain the stages of CLL. Moreover, we will also discuss the fluorescent in-situ hybridization FISH-based prognostic factors common genetic aberrations or mutations in CLL. In this paper we will also discuss about the methods for the treatment of lymphomas.

Keywords: Lymphocytic leukemia, miRNA, Biomarkers, Genetic mutations, Treatment methods.