SYNTHESIS AND ANTIGLYCATION ACTIVITY OF BENZENE-1,3,5-TRICARBOXYLIC ACID MEDIATED NEW SERIES OF SCHIFF BASE DERIVATIVES
K. P. Rakesh, C. S. Shantharam*, D. M. Suyoga Vardhan, N. M. Made Gowda, M. B. Sridhara and D. Channe Gowda
ABSTRACT
A series of benzene-1,3,5-tricarboxylic acid mediated Schiff base derivatives 4-15 were synthesized and characterized as novel antiglycating agents. The in vitro antiglycation activity of these compounds were evaluated and compared with standard Rutin (41.9 μM). Preliminary structure-activity relationship revealed that the compounds 6, 8, 12 and 14 with electron donating moiety (OH and OCH3) were found to be excellent antiglycating agents and compounds 5, 9, 11 and 13 with electron withdrawing (Cl and NO2) group showed least antiglycating activity. This study offers an opportunity for further structural modifications and extensions that could give rise to compounds with improved inhibitory profile against protein glycation.
Keywords: Schiff’s base, Antiglycation, Electronic effect.
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