INHIBITORY EFFECT OF ? - GLUCOSIDASE AND ? - AMYLASE ENZYME ACTIVITIES OF ADHATODA VASICA NEES

*Vadivelan R, Dhanabal SP, Santilna KS, Shirisha S.

ABSTRACT

Aim: The present study is to evaluate the in-vitro antidiabetic activity
of the ethanolic extract and fractions of Adhatoda vasica Nees by α-
glucosidase and α -amylase inhibitory activity. Methods: The leaves
of the Adhatoda vasica Nees was extracted using ethanol, and fractions
by using chloroform and n-butanol. The extract and fractions were then
used to study its α-glucosidase and α -amylase inhibitory activity
Results: Adhatoda vasica ethanolic extract and fractions showed dose
dependent inhibition of α-glucosidase and α -amylase enzyme and
exhibited lower inhibitory activity than acarbose. Conclusion: The study revealed the
antidiabetic potential and could be helpful to develop medicinal preparations and
nutraceuticals and function foods for diabetes.

Keywords: Adhatoda vasica, ?- Glucosidase/ ? - Amylase inhibitor, Diabetes, Nilgiris.