PREPARATION AND EVALUATION OF FERROUS GLYCINE SULPHATE TIMED RELEASE DOSAGE FORM

B. Shyamala Devi, R. Kumaravelrajan* and V. Suba

ABSTRACT

Objective: Extrusion spheronization is a widely used multi-stage technique that can produce spherical particles of almost uniform size. In order to evaluate the effect of the substitution of microcrystalline cellulose with different amounts of ethyl cellulose on the mechanical properties and release properties of ferrous sulphate glycine matrix particles prepared by extrusion spheronization, this study was conducted. Method: Therefore, the ethyl cellulose used in the formulation test ranges from 0-40%, and the maximum MCC is 85%. The yield of pellets was in the range of 70-90.5% and was influenced by EC percentage. Results: Inclusion of EC changed the mechanical properties of pellet, and affected drug release rate and therefore was able to make sustained release matrix pellets up to 4 hr it was observed that, the ferrous glycine sulphate pellets, as an iron compound was found to produce an improved effect comparing to the standard. Conclusion: Results revealed that EC could not be used as a sole polymer in production of Ferrous glycine sulphate matrix pellets by extrusion-spheronization and at least 20% level of MCC was necessary in the process. Data between groups were compared statistically by t-test and values of P<0.0001 were considered statistically significant.

Keywords: Ferrous glycine sulphate, Pellets, Timed-release, Extrusion-Spheroinzation.