WOUND HEALING ACTIVITY AND ANTI ULCER ACTIVITY OF ETHANOLIC EXTRACT OF PEELS OF ANANAS COMOSUS

Sowjanya K.*, Spandana U., R.R. Manjula, Havilah Esther S., Sravani T. and G. Shiva Nageswara Rao

ABSTRACT

Aim: To study the “wound healing” & “anti ulcer” activity of ethanolic extract of peels of Ananas comosus. Objectives: Prepare ethanolic extract of peels of Ananas comosus, to perform phyto chemical screening studies & evaluation of wound healing, anti-ulcer activities. Methods: The wound healing & anti-ulcer efficacy of ethanolic extract of peels of Ananas comosus was evaluated in excision wound model and aspirin induced ulcer method. The rats were divided into 4 groups with 6 rats in each group. Group 1 rats were treated with vehicle. Group 2 rats were treated with standard drug. Group 3 and 4 rats were treated with extract at 100 and 200mg/ kg bd wt respectively. Results: The percentage healing with Ananas comosus peel extract was significantly higher than standard from the 2nd day of treatment and continued till the completion of the treatment. The extract has a tremendous potential as a natural potent and safe alternative to conventional antiulcer treatment. Conclusion: The ethanolic extract of peels of Ananas comosus showed significant wound healing & anti-ulcer activity which is evident by the data obtained.

Keywords: Wound healing; anti-ulcer; ethanolic extract; Ananas comosus peel.