HUMAN GUT MICROBIOME: RELATION WITH VARIOUS DISORDERS AND ITS ASSOCIATED THERAPY USING PROBIOTICS

Elseena Jose *Mariya Joy, Shilpa Joseph, Anu Jayamol Mathew and Jisha Thomas

ABSTRACT

The developments in DNA sequencing technology and computational biology have revolutionized the world of microbiome, which in turn resulted in identifying the contributions of the microbiome to human health. Dysbiosis of the intestinal microbiota making up the human microbiome can have a marked influence on energy and immune homeostasis, which results in significant metabolic and immunologic effects on the host, ultimately leading to many local and systemic diseases including inflammatory bowel disease, asthma, obesity, metabolic syndrome, cardiovascular disease, immune‐mediated conditions, and neurodevelopmental conditions such as autism spectrum disorder. In this systematic review, we provide an overview of the evidence on the association between human gut microbiota and various disorders. Besides, we analyse the effects of microbiome-based therapies on the above disorders using probiotics.

Keywords: Gut dysbiosis, microbiome, cardiovascular, obesity, HIV, chronic inflammation, psychiatric disorders, cancer, Probiotics.