SYNTHETIC APPROACH TOWARDS SOME SUBSTITUTED SULPHONYLUREAS AND GUANIDINE DERIVATIVES AS HYPOGLYCEMIC AGENTS

Ishan I. Panchal*, Dr. Dhrubo Jyoti Sen and Dr. Samir K. Shah

ABSTRACT

Diabetes mellitus (DM) is a major degenerative disease associated with a group of disorders of carbohydrate metabolism results from body's failure to produce insulin in type 1 and insulin resistance in type 2 diabetes mellitus through altered secretion, decreased insulin activity known as hyperglycaemia. There is direct relationship between hyperglycemia and long-term complications such as retinopathy, nephropathy and neuropathy like micro and macrovascular concerns. Existing oral treatment options for T2DM include metformin, sulfonylurea, thiazolidinedione derivatives, glycosidase inhibitors and the recently Dipeptidyl peptidase IV inhibitors which have been introduced successfully. There remains avital need to improve new antidiabetic agents with higher efficacy and lower toxicity for the long term treatment of T2DM.Search for new innocent anti-diabetic agents is still a challenge for medicinal chemists. The detailed study of literature reviewand study we have decided to design and synthesis of novel antidiabetic agents. In order to reduce the space volume of this kind of molecule, we have designed and synthesized a series of cyclohexane, p-Nitro benzoic acid, p-Cl benzoic acid, Cinnamic acid derivatives of sulphonylureas and guanidine.All the synthesize compounds were characterized by melting points, TLC. IR spectroscopy,1H-NMR and 13C-NMR.The synthesized compounds will proposed for biological evaluation by most relevant animal models like alloxan induced diabetic animal model for in-vivo studies.

Keywords: Diabetes mellitus, sulphonylureas, DPP-IV inhibitors, IR, NMR, Mass.