ESTIMATION OF SERUM TOTAL SIALIC ACID IN ORAL LEUKOPLAKIA AND ORAL SQUAMOUS CELL CARCINOMA

Dr. Satyam Joshi*, Dr. Khushboo Desai, Dr. Hemal Joshi, Dr. Darshan Patel, Dr. Neha Verma and Dr. Bahar Roghany

ABSTRACT

Objectives: The purpose of this study is to investigate clinical usefulness of circulatory levels of Total Sialic acid in Leukoplakia, Squamous cell carcinoma and healthy controls of age and sex matched subjects. Method: Blood samples were collected from 30 untreated Leukoplakia, 30 untreated Squamous cell carcinoma and 30 healthy subjects. Total serum Sialic acid were evaluated by the simplified quick method by G Sydow and measured spectrophotometrically at 525nm. Results: Serum levels of Total Sialic acid were significantly elevated (P<0.001) in untreated Oral cancer patients as compared to healthy controls and Leukoplakia. Our data also inferred significant difference between 1)control group & Leukoplakia group, 2)control group & squamous group and 3)Leukoplakia group & squamous group with respect to the mean Sialic acid levels (P<0.001). Conclusion: The data revealed direct relation between significant elevation of serum Total Sialic acid levels in Oral cancer patients and also an ascending order of increase of serum Total Sialic acid levels from healthy controls to Leukoplakia to Squamous cell carcinoma and suggested that potential utility of these parameters in initial diagnosis of Leukoplakia and Squamous cell carcinoma.

Keywords: Leukoplakia, Oral cancer, Sialic acid, Squamous cell carcinoma.