MOLECULAR DOCKING STUDIES OF NATURAL ANTIMICROBIAL COMPOUND FROM SARGASSUM WIGHTII AGAINST SELECTED TARGETS OF PATHOGENS

Ashtalakshmi G.* and P. Prabakaran

ABSTRACT

Sargassum species are distributed worldwide with great ecological and economic importance in marine ecosystems and bioresources. These are nutritious and rich source of bioactive compounds such as vitamins, carotenoids, dietary fibers, proteins, and minerals. Also, many biologically active compounds like terpenoids, flavonoids, sterols, pheophytine sulfated polysaccharides, polyphenols, sargachromenol, sargaquinoic acids, were isolated from Sargassum species. Specific targets were selected from pathogens occurs in diabetic foot infection, namely Pseudomonas aeruginosa, Klebsiella Pneumoniae, Escherichia coli, Staphylococcus aureus and Candida albicans. Various active compounds were selected from Sargassum wightii exibiting antimicrobial activity. Molecular docking studies were performed using Autodock 4.0 server. Among the two compounds each have been screened and docked for binding energy analysis, the potential docked structure confirmed the antimicrobial activity and support our invitro results.

Keywords: Sargassum wightii, brown algae, diabetic foot infection.