ANTIHYPERGLYCEMIC ACTIVITY OF BARK OF ELAEODENDRON GLAUCUM PERS. EXTRACTS ON BLOOD GLUCOSE LEVELS OF STREPTOZOCIN INDUCED DIABETIC RATS

Sanjiv Mittal*, Pradeep Goyal and Dr. A. K. Singhai

ABSTRACT

The prevalence of diabetes mellitus continues to rise worldwide and treatment with oral hypoglycemic drugs leads to numerous side effects and huge monetary expenditure. Therefore, active research on identification of new anti diabetic drugs with minimal side effects from medicinal plants is a challenge according to WHO recommendations. In this aspect, the present study was undertaken to evaluate the antidiabetic potential of Elaeodendron glaucum Pers. bark in streptozocin (STZ) induced diabetic rats. Diabetes was induced in albino wister rats by intraperitoneal administration of STZ (45 mg/kg b.wt). Fasting blood glucose (FBG) levels were measured by glucose-oxidase & peroxidase method. The statistical analysis of results was carried out using and one-way analysis (ANOVA) followed by Student’s t-test. Antidiabetic potentials of bark of E. glaucum Pers. extract has been investigated at the doses of 150, 300 and 600 mg/kg b.wt orally administered against streptozocin induced diabetes male wistar rats. Treatment of streptozocin diabetic male wistar rats with the extracts caused a significant (P<0.01) reduction in the blood glucose levels. The highest activity resides at the dose of 600 mg/kg b.wt with mean percentage change of 57.79% after 28 days of extract administration while the other two doses 150 and 300 mg/kg have changes of 41.88% and 43.12% respectively. This result suggests that the bark of E. glaucum Pers. extracts possess antidiabetic effect on streptozocin induced diabetic male wistar rats.

Keywords: Antihyperglycemic activity, Streptozocin, Elaeodendron glaucum, Diabetes mellitus