COMPARATIVE EVALUATION OF THE EFFICACY OF TOPICAL AMLEXANOX 5% ORAL PASTE AND TRIAMCINOLONE ACETONIDE 0.1% ORAL PASTE IN THE TREATMENT OF MINOR RECURRENT APHTHOUS STOMATITIS -A SYSTEMATIC REVIEW AND META-ANALYSIS

Dr. Daya K. Jangam*, Dr. Sunaina Swatantramath, Dr. Kajol Talreja and Dr. Pranali Bahadure

ABSTRACT

Aim: The aim of this systematic review was to compare the clinical efficacy of topical triamcinolone acetonide 0.1% and amlexanox 5% in minor (RAS) treatment. Background: The term ―aphthous‖ is derived from a Greek word ―aphthae‖ that means ulceration. Minor Recurrent aphthous stomatitis (RAS) comprises more than 80 to 90% of aphthous stomatitis cases, most commonly seen in second to fourth decade of life.[1] Variety of treatment modalities exist which consists of measures to suppress the symptoms as well as reduction in pain and duration of healing of ulcers. Amlexanox is a topical anti-inflammatory, antiallergic drug. It is presently the sole clinically established product approved by the US Food and Drug Administration for the treatment of minor recurrent aphthous ulcers.[1] Triamcinolone Acetonide is a topical corticosteroid drug which has anti-inflammatory & immunosuppressive action used in the treatment of minor RAS.[2] Search Method: With the available literature from PubMed, Google Scholar and grey literature. Data Collection & Analysis: The protocol of this review was primarily based totally on the PRISMA, PRISMA pointers and listing were followed so as to extend the standard and transparency of the search. Recommendations of the Cochrane enchiridion and Systematic Reviews of Interventions were followed. Meta- analysis was done based on Pearson’s value. Results: Five studies out of ninety five studies were included showed significantly higher potency of Triamcinolone compared to amlexanox for minor RAS treatment regarding pain, healing, and ulcer size reduction. Conclusion: Triamcinolone acetonide 0.1% is more effective than Amlexanox 5% in the treatment of minor RAS. Clinical Significance: Efficacy of two topical ointments in management of minor recurrent apthous stomatitis was assessed to understand, reduction in pain, reduction size and ulcer duration of healing in patients.[5] The clinical results of this review provide scientific evidence about the efficacy of Topical Amlexanox 5% Oral Paste and Triamcinolone Acetonide 0.1% Oral Paste.

Keywords: Amlexanox 5%, Triamcinolone Acetonide 0.1%, recurrent apthous stomatitis, apthous ulcer.