RECENT APPROACH OF PULSATILE DRUG DELIVERY SYSTEM: AN OVERVIEW

Omkar Tipugade*, Manohar Patil, Sayali Bhurke, Pallavi Chavan and Shobharaj Malavi

ABSTRACT

Pulsatile Drug Delivery Systems are gaining popularity because they deliver drugs at the right place, at the right time, and in the right amount, ensuring spatial, temporal, and smart delivery while also improving patient compliance. Many medications or therapies could benefit from a pulsatile drug release, in which the drug is released rapidly after a predetermined lag time. A pulse must be designed in such a way that after the lag time, a complete and rapid drug release is achieved, matching the body's circadian rhythms with the drug release, increasing the efficacy and safety of drugs by proportioning their peak plasma concentrations during the 24 hours in synchrony with biological rhythm. In recent years, various technologies for chronopharmaceutical drug delivery have been developed and thoroughly explored, including time-controlled, pulsed, triggered, and programmed drug delivery systems. To administer medicine in a pulsatile way, many types of formulations such as bilayer tablets, coated tablets, pellets, and tablet in capsule can be developed.

Keywords: Pulsatile Drug Delivery System, Chronopharmaceutics, Rhythm of Disease, Technologies, Future aspects.