ANTI-INFLAMMATORY ACTIVITY OF ACACIA CONCINNA

Megha Agrawal* and Dr. Vijay Patel

ABSTRACT

The aqueous extract of the pods of Acacia concinna was investigated for its anti-inflammatory activity using carrageenan induced paw edema and cotton pellet granuloma models in wistar rats. A statistically significant (p<0.01) dose and time dependent inhibition of edema was observed. The observed % inhibition of edema was 77.78, 69.44 and 62.04% for ibuprofen and plant extract with 100 and 200 mg/kg dose, respectively. Also, the plant extract significantly inhibited (p<0.01) the granuloma induced by cotton pellets in rats in a dose-dependent manner. The % granuloma inhibition was 51.21, 26.12 and 30.59% for ibuprofen and plant extract at doses of 100 and 200 mg/kg respectively. It was concluded from the present study that extract of pods of A. concinna have significant anti-inflammatory activity.

Keywords: Anti-inflammatory, Acacia concinna, Paw edema, Cotton pellet granuloma.