PEMPHIGUS VULGARIS: CASE WITH DIAGNOSTIC DILEMMA

*Dr. Debarati Deb, Dr. Rupam Sinha, Dr. Subhadeep Maity, Dr. Harshvardhan Jha, Dr. Mainak Datta Dr. Sthita Datta

ABSTRACT

Pemphigus Vulgaris is an autoimmune disease which can cause blistering of the skin and mucous membrane; they are fragile and break away leaving extremely painful erosions. The mechanism behind this is the binding of immunoglobulin G(IgG) autoantibodies to desmoglein(DSG) 1 & 3. Histological feature shows intraepithelial cleft and Tzanck cells. In these case reports; we discussed two cases of pemphigus vulgaris in oral cavity with their clinical manifestations. We have also reported the effect of treatments after two consecutive recalls where the patient got satisfactory relief from their previous signs and symptoms.

Keywords: Autoimmune, desmoglein, pemphigus, corticosteroid.