EVALUATION OF ANTIDIABETIC ACTIVITY OF ROOTS OF TINOSPORA CORDIFOLIA ON EXPERIMENTAL ANIMALS

Anurag Gaur*, Praveen Kumar, Dr. Shamim Ahmad, Jiyaul Hak, Dr. Nasiruddin Ahmad Farooqi

ABSTRACT

The present study was an attempt to investigate the effect of T. cordifolia root extract on streptozotocin induced diabetes in Wistar rats. Two gropus of streptozotocin-induced diabetic rats were orally treated with T. cordifolia root extract (150 and 300mg/kg) respectively. The blood glucose level, body weight, Glycosylated hemoglobin, liver glycogen, lipid profile, Antioxidant status were measured at the end of the study i.e. after 40 days of treatment. T. cordifolia root extract were found to be significant (p < 0.05) in reducing the blood glucose level, glycosylated hemoglobin, lipid profile, whereas both the treatments increased body weight, liver glycogen content and antioxidant status when compared to the diabetic control. It has been concluded that T. cordifolia root extract, in addition to the antidiabetic activity, also possess antihyperlipidemic and antioxidant activities in the streptozotocininduced diabetic model.

Keywords: Two gropus of streptozotocin-induced diabetic rats were orally treated with T. cordifolia root extract (150 and 300mg/kg) respectively.