STUDY THE EFFECT OF QUERCETIN AGAINST SORTILIN-RELATED RECEPTOR TO CURE ALZHEIMER’S DISEASE

Km. Radha, Niketa Singh, Khushboo Rana, NoopurKhare and Abhimanyu Kumar Jha*

ABSTRACT

Alzheimer‟s disease [AD] is one of the most common types of Neurodegenerative disease in worldwide. It is the most common type of disease which causes dementia in the elderly. The molecular docking technique is used for observing the interaction between ligands and a target protein-making drug. Molecular docking has a vital role in drug discovery. So, this technique plays a vital role for screening the natural compounds with target protein, it depends upon binding energies. The molecular docking is helps in investigates the expression of SOR1 protein with natural compound Quercetin for the prepration of drug to treat Alzheimer‟s disease In 1906, Dr. Alos Alzheimer‟s noticed that the changes in the tissue of the brain in a “woman” who had died of a usual mental illness. Dr. Alos Alzheimer‟s gives their named Alzheimer‟s disease. Molecular docking has become an increasingly important tool for drug discovery. The PDB was recognized in the year 1971 for all protein data collected in a particular platform, which is the universal platform of biological protein structural data.

Keywords: Auto Dock Vina, AD, SOR1, Ligand and Molecular docking.