LYMPHOMA ORBIT – A 4 YEAR STUDY AT A TERTIARY CARE CENTRE

Dr. Syeda Sumaiya Fatima, *Dr. K. Sampurna and Dr. J. Anunayi

ABSTRACT

Over the last few decades, our understanding of orbital lymphoproliferative lesions has undergone profound change. The primary impetus has been the advent of increasingly sophisticated and specific immunodiagnostic and molecular techniques in tissue pathology. Accurate discrimination of orbital lymphoma from benign orbital lymphoproliferative disorders is crucial for treatment planning. A four year prospective study was carried out at tertiary care centre. All cases of clinically suspicious lymphomas, proven by CT and Histopathology were included. Incisional or excisional biopsy specimens were received for histopathological examination, and tissues were fixed in 10% formalin for processing. Sections were processed routinely with paraffin embedding and stained with haematoxylin and eosin. Immunohistochemistry was done wherever required. We analyzed in total of 86 cases with the clinical suspicion of orbital lymphoma from June 2016-May 2020. All these cases were included initially regardless of age and sex. Of these 49 cases proved to be cases of lymphoma orbit and the remaining 37 cases were excluded from the study as they were not lymphomas. The lymphomas were then subjected to immune histochemistry profiling which showed largely B cell neoplasms (87.77%)- with small lymphocytic lymphoma being the most common tumor - 21 cases (48.9%) followed by 11 cases (25.58%) of mixed small and large cell, 8 cases (18.6%) of large cell B cell lymphoma and 3 cases (6.9%) of Burkitts lymphoma. Primary lymphoid tumour of the orbit are not very uncommon. Histopathology remains the gold standard for diagnosis followed by proper immunohistochemistry profiling of the lesion for definitive treatment.

Keywords: Orbital, Immunohistochemistry, Small lymphocytic lymphoma, Burkitts Lymphoma.