PEANUT HUSK POWDER AS A SUPER-DISINTEGRATING AGENT IN THE FORMULATION OF FAST DISSOLVING TABLETS OF DOMPERIDONE

G. Chandra Sekhara Rao*, V. Jyothi, N. Indravathi and S. Gangarathnam

ABSTRACT

The rapid growth of novel drug delivery systems has resulted in an increase in the number of excipients being used in solid dosage forms in pharmaceutical industry. This includes both new materials and new physical forms of existing materials to improve the physicochemical properties of tablet dosage forms. The aim of the present work was to evaluate peanut husk powder, as a disintegrating agent in the formulation of fast dissolving tablets of Domperidone. Total six formulations were designed using different disintegrating agents and quality control tests like weight variation, hardness, friability, disintegration and dissolution were carried out for the prepared tablets. The obtained results were tabulated and analyzed. The prepared tablets were found to pass all the quality control tests performed. The formulation containing peanut husk powder as disintegrating agent was found to be the best formulation among all others. Peanut husk powder obtained from natural plant seeds was found to be a promising super-disintegrating agent from this research work.

Keywords: Fast dissolving tablets, peanut husk powder, super-disintegrating agent, Domperidone, swelling capacity, wetting time.