SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL MANNICHBASES OF N-SUBSTITUTED TETRAHYDROCARBAZOLE DERIVATIVES

M. Sangeetha* and C. Rubina Reichal

ABSTRACT

Tetrahydrocarbazole is an important class of heterocyclic compound which plays a vital role in the field of medicinal chemistry. The aim of this research work is to synthesise some novel mannich bases of N-Substituted teterahydrocarbazole derivatives. Teterahydrocarbazole were prepared by fischer indolisation reaction of cyclohexanone with phenylhydrazine in the presence of acetic acid. The mannich bases of these compounds were synthesized by reacting with different aldehydes and P-Aminobenzoic acid. The structures of synthesized derivatives were confirmed by IR, NMR and Mass spectrum. The synthesized compounds were evaluated for antimicrobial activity by cup plate method.

Keywords: Tetrahydrocarbazole, Mannich bases, Antimicrobial activity.