A RETROSPECTIVE STUDY OF THYROID HORMONE AND GROWTH IN PEDIATRICS: RELATIONSHIPS WITH GROWTH HORMONE EFFECTS CORRELATION WITH OBESITY IN RIYADH, SAUDI ARABIA

Dr. Abdullah Hamad Alfaris*, Dr. Faisal Mujeb Alshareef, Dr. Feras Ghazi Alhazmi, Dr. Ahmed Enad Alenazi, Abdullah Samir Aldarwish, Ziyad Alluwaymi, Saif Saad Altuwairqi, Abdulaziz Alqarni, Abdullah Alkahtani, Abdulwahab Alshamrani, Fahad Bin Abbas, Faisal Alsukairan, Mohammed Alfadhel, Mohammad Kaled Almazied and Khalid Ahmed Aljasser

ABSTRACT

Research in the field of growth endocrinology has been mainly focused on growth hormone (GH) and growth deficiency correlation of risk of obesity. Morbidly obese subjects are characterized by multiple endocrine abnormalities, and these are paralleled by unfavorable changes in body composition. In obese individuals, either 24-h spontaneous or stimulated GH secretion is impaired without an organic pituitary disease and the severity of the secretory defect is proportional to the degree of obesity. The aim of the present study was to investigate the relationships between decreased GH secretion and body composition in a group of pediatric populations. However, it appears that GH does not always control growth rate. For instance, it does not clearly influence intra-uterine growth ،in addition, GH does not always clearly stimulate somatomedin production, particularly daring food restriction and fetal life, associated with a reduced T3 production, suggesting a significant influence of thyroid function on GH action, and more generally, on body growth.

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