AN OVERVIEW: IN-SITU GEL AND MODERN OCULAR DRUG DELIVERY SYSTEM

Parag G. Nakhare*, Omkar Tipugade, Shobharaj Malavi and Sadanand Khair

ABSTRACT

Ocular Drug Delivery has been a significant testing and intriguing field for the pharmaceutical researcher because of novel life structures and physiology of eye. The poor bioavailability of conventional ophthalmic formulations is due to rapid pre-corneal drug loss (through dilution and drain from the eye). The matter will be overcome by in situ forming ophthalmic drug delivery system ready from chemical compound (polymer) that exhibit reversible liquid-gel phase transition. In situ gels are the liquid preparations which upon instillation undergoes phase transition in cul-de-sac of the eye to make a viscous gel and this happens because of the environmental changes within the eye (i.e. This novel drug delivery system promotes the significantly ease and convenience of administration, retrieval of correct dose as well as to prolong residence time of drug in contact with mucosa. This review is to specify the essential anatomy and physiology of human eye, numerous approaches used for formulation of in-situ gels and polymers utilized in the formulation of in situ gels.

Keywords: Ocular drug delivery, In-situ gel, Biodegradable polymer, PH sensitive, Temperature sensitive, Ion sensitive.