FIBRODYSPLASIA OSSIFICANS PROGRESSIVA [FOP]: A REVIEW

Dondapati Lakshman Chaturvedhi*, K. Malleswari, D. Rama Brahma Reddy and B. Prasanna Kumar

ABSTRACT

Fibrodysplasia ossificans progressiva (FOP) is also known as Munchmeyer disease, Stoneman disease. It is a rare inherited connective tissue disease characterized by heterotopic ossification (atypical development of bone in the regions of the body where bone is not generally presen). A mutation in the gene ACVR1 is responsible for the disease. Specifically, ossification is typically first seen in the dorsal, axial, cranial and proximal regions of body. Diagnosis can be done by measuring clinically elevated levels of alkaline phosphatase. There is no approved treatment for FOP.

Keywords: Heterotopic ossification, ACVR1 gene, Alkaline phosphatase.