A COMPARATIVE STUDY OF EFFICACY WITH FIXED DOSE COMBINATION OF LATANOPROST/ TIMOLOL VERSUS BRINZOLAMIDE/ BRIMONIDINE IN PRIMARY OPEN ANGLE GLAUCOMA

Chawla S.*, Kaushal J. and Sachdeva S.

ABSTRACT

Objective: To study efficacy with fixed dose combination of latanoprost/ timolol versus brinzolamide/brimonidine in primary open angle glaucoma. Material & Methods: A prospective, randomized, comparative, clinical study was conducted on 50 patients. The patients were randomly divided in two groups of 25 each to receive following two treatments: Group A (n=25) Latanoprost and Timolol (0.005+0.5%w/v) ophthalmic solution once daily; Group B (n=25) Brinzolamide and Brimonidine (1%+0.15%w/v) ophthalmic solution thrice daily for 12 weeks. Efficacy assessment was done at the end of 2, 4, 6 and 12 weeks by observing Intra Ocular Pressure (IOP), visual acuity assessment, number of patients having headache, eye-ache & assessment of VAS score for headache & eyeache was also done. Results: Intraocular Pressure assessment using Goldmann applanation tonometer was done in both the groups. IOP in Group A at the end of 12 weeks was 19 as compared to 27.6 at the baseline while in group B it was 20 as compared to 26.76 at the baseline. The difference was statistically significant at the end of 12 weeks; p<0.001. Improvement in mean vision in Group A was more than Group B at the end of 12 weeks (33.3% Vs 15.2%) but the difference was not statistically significant. Reduction in VAS score for headache & eye-ache was more with Group A as compared to Group B at the end of 12 weeks but the difference was statistically different.

Keywords: Latanoprost, Timolol, Brinzolamide, Brimonidine, Intra Ocular Pressure, Mean vision, headache, eye-ache, visual acuity score.