FORMULATION APPROACHES FOR NASAL DRUG DELIVERY SYSTEM - A REVIEW

Harshada Rokade*, Monika Ola, Somnath Tambade, Rajveer Bhaskar and Shwetal Pawar

ABSTRACT

Most oral drugs have low bioavailability and limited bioaccessibility to the brain with rapid biotransformation, unwanted side effects, and high costs all of which are distressing to patients. The intranasal route of drug administration promotes better bypass across the blood brain barrier and reduces systemic side effects by reducing the frequency of dose administration. Drugs administered via the nasal route generally have high bioavailability, higher brain exposure at a lower dose than the oral dose with fewer side effects. It presents some possibilities for improving drug penetration through the nasal barrier and summarizes some in vitro, ex vivo and in vivo technologies for testing drug release through the nasal epithelium in the brain. In this review article includes, physiology of nose and nasal to brain drug delivery approaches.

Keywords: Nasal drug delivery systems, Vivo and Vitro technologies to test drug delivery through the nasal epithelium of the brain.