INHIBITORS OF CANCER STEM CELL

Patil Shubham P.*, Vetal Swati K., Aher Prajwal R., Gedam Shweta S. and Jadhav Anil G.

ABSTRACT

These stem cells have ability of self-renewal, and intrinsic survival mechanisms which helps to maintains growth of tumour cells. Now they are considered auspicious therapeutic targets in the treatment of the cancer. These cancer stem cells also have resistance to the chemotherapy. They contribute to multiple tumour malignancies, such as repetition, metastasis, heterogeneity, resistance to many drugs, and also resistance to various radiations. Targeted therapies are directly related to suppressing or eliminating cancer stem cells may synergize with well-known therapies and increase efficacy. Enhanced understanding of CSC markers, such as CD133, CD44, and epithelial cell adhesion molecule (EpCAM), may facilitate development of therapies that target them. These gives review on information about CSC, its inhibitors, and its working on cancer cells.

Keywords: Adenocarcinoma, Chemotherapy, Malignant, Immunosuppressive, CD133, CD44, Hedgehog, Wnt, Verteporfin, Curcumin.