A REVIEW ON BIOLOGICAL ACTIVITY OF DIHYDROPYRIMIDINONE (DHPM) DERIVATIVES:

Dr. Abhishek Soni, Priyankul Palia, Nagesh Kumar* and Mukul Sharma

ABSTRACT

The most important heterocyclic ring systems that play a role in the synthesis of DNA and RNA are dihydropyrimidines. They were made synthetically using multi-component reactions such as the Biginelli reaction and the Hantzschdihydropyridine reaction. Due to the interesting pharmacological properties associated with this heterocyclic scaffold, Biginelli type dihydropyrimidones have received a lot of attention in recent decades. In this review, we concentrate on the DHPMs, which have recently been developed as calcium channel antagonist, antiinflammatory, anti-tubercular, anticancer, and antibacterial activities.

Keywords: heterocyclic scaffold, Biginelli type dihydropyrimidones.