MUCORMYCOSIS: A DETAIL REVIEW

*Gaurav Sanjay Mahalpure and Sakshi Sanjay Mahalpure

ABSTRACT

Mucormycosis was previously called zygomycosis. It is a rare angio invasive infection that occurs due to fungi Mucorales with high morbidity and mortality. This infection highly recognizes in immunosuppressed patients. Immunosuppressed states such as hematological malignancy, bone marrow or peripheral blood stem cell transplantation, solid organ transplantation, neutropenia, diabetes mellitus with or without ketoacidosis, corticosteroids, and deferoxamine therapy for iron overload predispose patients to infection. This fungal infection can list as rhino-orbitocerebral, cutaneous, gastrointestinal, disseminated, and pulmonary types. The mortality rate can come 100% depending on the patients underlying disease and the form of mucormycosis. In India, the prevalence of mucormycosis is about 80 times the prevalence in developed countries, being approximately 0.14 cases per 1000 population. The main aim and intention of this review are to providing with brief information about the aetiology, epidemiology, symptoms of mucormycosis, fatality of rhinocerebral mucormycosis, along recent advances in diagnostic and treatment.

Keywords: Mucormycosis, Zygomycosis, Pathophysiology, Rhinocerebral mucormycosis, Amphotericin B.