FORMULATION AND EVALUATION OF TRANEXAMIC ACID MICROSPONGES FOR TOPICAL DRUG DELIVERY SYSTEM

Rakesh S. Pawara*, Nileshwari P. Chaudhari, S. A. Tadavi and S. P. Pawar

ABSTRACT

Tranexamic acid it belong to a class of drugs known as antifibrinolytic, thereby preventing prolonged bleeding and slowing the breakdown of clots. the present study was taken to the development of topical drug delivery of formulation to the facilitate the controlled release of active drug into the skin, release of the drug into skin are controlled in manner and reduces the side effect or improved in the product efficiency. generally microsponges are mainly release of the drug and enhance the stability and effectively reduce the side effect of drug. Tranexamic acid loaded microsponges were prepared by using the Quasi-emulsion solvent diffusion method. having all nine formulation of tranexamic acid microsponges prepared by using polymer eudragit S100. Prepared microsponges were analyzed for the partical size, flow property of the microsponges, production yield, Drug loading efficiency, drug content and In-vitro drug release study. Microsponges are having a spherical in shape having a polymeric porous in nature.

Keywords: topical drug delivery system, microsponges, tranexamic acid, polymeric porous, eudragit S 100.