THE ANTICOAGULANT ACTIVITY OF VIBHITAKA PHALA TWAK (TERMINALIA BELLIRICA (GAERTN.) ROXB.) – INVITRO STUDY

*Dr. Namita Dinesh Kalgutkar, Dr. Sneha Shaji and Dr. Lalitha B. R.

ABSTRACT

The Kashaya kalpana is one of the liquid dosage forms which can provide maximum therapeutic efficacy prepared by using drug and water in specific proportion and reducing it to particular quantity. The concept of Saptavidha kashaya explained by Acharya Harita is a reductive dosage form. The Saptavidha Kashayas are Pachana kashaya, Deepana kashaya, Shodhana kashaya, Shamana kashaya, Tarpana kashaya, Kledana kashaya, and Vishoshi kashaya. The vishoshi kashaya which has highest reduction that is Shodhashamsha (1/16th) and has shoshana karma and this concept is considered in study to evaluate the anticoagulant activity. The drug, Vibhitaka phala twak, selected for the present study based on its kashaya rasa, laghu and ruskha guna is assessed to have shoshana karma in turn lekhana karma. The vishoshi kashaya of vibhitaka phala twak was subjected to analytical evaluation and an in-vitro study for screening Anti-coalgulant activity and was carried out by Lee- white method and Haem-hydrolysis method. Invitro study carried out, revealed the Anti-coalgulant activity. Presence of Ellagic acid, Triterpenoids, and Aglycone Saponins are responsible for the anti-coagulant activity of Vishoshi kashaya of Vibhitaka phala twak.

Keywords: Ayurveda, Vibhitaka phala twak, Vishoshi Kashaya, Shoshana and Lekhana karma, Anticoagulant activity.