ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF HYDROALCOHOLIC EXTRACT OF ROOTS OF AEGLE MARMELOS

Aaradhna Patel*, Deepika Bairagee, Neetesh Kumar Jain and Sumeet Dwivedi

ABSTRACT

The aim of the present study is to determine the analgesic and anti-inflammatory activity of hydroalcholic extract of roots of Aegle marmelos. The extract was found to have significant anti-inflammatory activities by carrageenan caused inflammation. This effect is almost comparable to Indomethacin or slightly less. Aegle marmelos extract found to have significant analgesic activity by thermal stimulation pain. The effect is almost comparable to Diclofenac and Morphine sulphate or slightly less. Aegle marmelos in the dose of 100 mg per kg and 200 mg per kg of body weight increased paw licking (Eddy' s hot plate) time. The results of dose level Aegle marmelos 100 mg per kg and 200 mg per kg of body weight are comparable to the indomethacin, as seen from the studies. The results of dose level of Aegle marmelos 100 mg/kg and 200 mg/kg body weight are comparable to the Diclofenac and morphine sulphate, as seen from the studies.

Keywords: Analgesic and anti-inflammatory activity; Hydroalcoholic extract; Aegle marmelos; Diclofenac; Morphine.