ACUTE TOXICITY STUDIES AND EVALUATION OF ANTI- INFLAMMATORY ACTIVITY OF ETHANOLIC EXTRACT OF LEAVES OF CELASTRUS PANICULATUS

Amjad Pasha*, Dr. Pavan Kumar, Dr. Sadath Ali, Dr. Shaik Mohammed Khasim, Dr. Parwez Alam and Buthul Fathima

ABSTRACT

The study was performed to evaluate the acute toxicity and anti-inflammatory effect of ethanolic extract of leaves of Celastrus paniculatus. The effect of Celastrus paniculatus, Ethanolic extract was studied for oral acute toxicity using type of Examinations like Clinical symptoms, Mortality, Body weight, Pathological examination and carrageenan induced paw oedema, method for studying anti-inflammatory activity respectively. The results of the acute toxicity studies indicate that the LD50 of Ethanolic Extract of leaves of Celastrus paniculatus (EECF) is more than 2000mg/kg. mortality was not observed in any group. Effect of ethanolic extract of leaves of Celastrus paniculatus on anti- inflammatory activity was evaluated by using carrageenan induced paw oedema method and cotton pellet induce glaucoma method. Percentage of anti-inflammatory increased in EEGF groups when compared to carrageenan induced animals. The different concentration of Celastrus paniculatus showed prompt anti-inflammatory activity.

Keywords: Celastrus paniculatus, Ethanolic extract, acute toxicity, anti-inflammatory activity.