CASE REPORTS ON SEVERE HEMOPHILIA A PRESENTING IN A NEWBORN WITH GERMINAL MATRIX HEMORRHAGE WITH HEMATOMA IN LIVER AND HEMIPERITONEUM

Dr. Radhika Sharma, Dr. Divya Rana and Dr. Ravi Verma*

ABSTRACT

Hemophilia A is an X-linked hereditary condition that leads to decreased factor VIII activity. Subsequently, leading to increased risk of bleeding events. During neonatal period, diagnosis is made after post-partum complication or unexpected bleeding after medical procedure. Germinal matrix hemorrhage during neonatal period is rare, severe intracranial bleeding with high mortality. We present a neonate with unremarkable family history and uneventful pregnancy with a vaginal delivery with no instrumentation, presenting with progressive pallor and shock at 36hours of life. The unexpected pallor and shock lead to a coagulation study and hemophilia A was diagnosed. This case shows the rare presentation of hemophilia A as intracranial bleeding with liver hematoma and hemiperitoneum.

Keywords: Factor VIII level, Hemophilia A, neonates.