STUDY OF CYP11B2 (1799998) GENE POLYMORPHISM IN PATIENTS WITH CHRONIC HEART FAILURE

*Nuriddin Anvarkhodjaevich Nuritdinov

ABSTRACT

Background: The aim of this study was to study the polymorphism of the aldosterone synthase gene CYP11B2 (1799998) in CHF patients. Methods: To conduct a genetic study, 152 patients with CHF aged 35-60 years of Uzbek nationality were examined, the average age of which was 53.9 ± 7.4 years. The control group consisted of 102 healthy people of Uzbek nationality. Results: Analysis of the results on the study of the characteristics of the allelic polymorphism of the CYP11B2 gene (rs1799998) aldosterone synthase among CHF patients revealed a trend towards an increase in the number of T / T homozygotes of the rs1799998 locus of the CYP11B2 gene in the group of CHF patients with high odds ratios, indicating an increased risk of developing CHF. Conclusion: The mutant T / T genotype of the CYP11B2 gene polymorphism (rs1799998) can be considered as an independent genetic marker associated with severe renal dysfunction accompanied by a significant decrease in GFR in CHF patients.

Keywords: chronic heart failure, gene polymorphism, kidney dysfunction.