INCLUSION COMPLEXATION OF REPAGLINIDE WITH BETA CYCLODEXTRIN TO IMPROVE SOLUBILITY

Simachal Panda* and Sreemoy Kanti Das

ABSTRACT

Repaglinide is an antidiabetic drug having low solubility due to its crystalline nature. Drug is coming under class II BCS classification. Here it is an attempt to improve solubility by inclusion complexation method. For this research work cyclodextrin was used. Cyclodextrin is derived from starch. It of different types alfa, beta and gamma cyclodextrin. Depending upon number of sugar moiety cyclodextrins are classified. Cyclodextrine used in research work for complexation with Repaglinide. X ray Diffraction study was conducted for both pure drug and complex .The pure drug shows sharp peaks in graph which reflects nature of crystallinity. Inclusion complexation was done by Physical mixture and kneading method. Volume, temperature and solvent was optimised. After complexation micromeritics and in vitro dissolution tests were conducted. Which gave satisfactory results. Calibration curve was done with distilled water. Phase solubility study was conducted.

Keywords: X Ray Diffraction, Phase solubility, BCS, crystallinity, amorphous.