ARCHAEOSOMES: INNOVATIVE APPROACH FOR MODERN DRUG DELIVERY PERSPECTIVESERY PERSPECTIVES

Madhukar Shende*, Shweta Ghode, Satish Bodele, Aparna Shende and Nilesh Nalawade

ABSTRACT

Archaeosomes, or liposomes made up of one or more ether lipids unique to the Archaeobacteria domain, are a novel kind of liposome found in Archaea. The fundamental structures of Achaean-type lipids are archaeol (diether) and caldarchaeol (tetraether). Traditional techniques (hydrated film sonicated, extrusion, and detergent dialysis) may be used to create archaeosomes at any temperature in the physiological range or lower, enabling thermally stable compounds to be encapsulated. A number of physiological and environmental factors have an impact on its stability. Archaeosomes are often used as drug delivery systems for cancer vaccines, Chagas disease, proteins and peptides, gene delivery, antigen delivery, and natural antioxidant compounds. The primary aim of this study was to examine the applications of this new carrier technology in the pharmaceutical industry.

Keywords: Archaeosomes, Archaeobacteria, Drug Delivery, Cell Delivery, Applications, Formulations.