EVALUATION OF ANTIHYPERLIPIDEMIC ACTIVITY OF ETHANOLIC EXTRACT OF GLYCOSMIS PENTAPHYLLA IN HYPERLIPIDEMIC WISTAR RATS

Syed Safiullah Ghori*, M.A Rizwan Khan,Kaab e Alam,Abid Hussain Abrar,

ABSTRACT

The present study was designed to perform preliminary phytochemical
screening, acute oral toxicity and to evaluate antihyperglycemic
activity of whole plant of Glycosmis pentaphylla ethanolic extract.
.Glycosmis pentaphylla,whole plant was extracted using ethanol as
solvent by soxhlet apparatus. The extract was subjected to preliminary
phytochemical screening. Acute oral toxicity studies were performed
to determine test dose. The evaluation of antihyperlipidemic activity was done using Triton
X 100 and High Fat Diet induced hyperlipidemia models in Wistar albino rats. Preliminary
phytochemical screening revealed the presence of alkaloids, carbohydrates, glycosides,
saponins, tannins, flavonoids, proteins, and amino acids. Doses up to 2000mg/kg were found
to be safe after acute toxicity tests. Cholesterol, triglycerides, HDL, LDL, VLDL, SGOT,
SGPT, Total protein and glucose were measured. The results suggested that EGP (ethanolic
extract Glycosmis pentaphylla) possess antihyperlipidemic activity against hyperlipidemia
induced by Triton X 100 and also High Fat Diet induced experimental models.

Keywords: Glycosmis pentaphylla,ethanolic extract, Triton-X, HFD, hyperlipidemia,.