CLINICAL PROFILE OF SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) AND SPECTRUM OF ORGAN INVOLVEMENT: AN OBSERVATIONAL, CROSS-SECTIONAL, HOSPITAL BASED, SINGLE CENTER STUDY

Yasmeen Hynniewta*, Alakes Kumar Kole and Anirban Jana

ABSTRACT

Background: Systemic Lupus Erythematosus(SLE), is an autoimmune disorder affecting various organs and tissues. This observational, cross-sectional, hospital based, single center study undertaken in Nilratan Sircar Medical College and Hospital, Kolkata, was aimed to assess the clinical profile of SLE and spectrum of organ involvement. Materials and Methods: Between December 2015 to June 2017, 60 patients who were diagnosed cases of SLE according to Systemic Lupus Collaborating Clinics (SLIC) Criteria attending either outpatient or admitted at the medicine department of Nilratan Sircar Medical College and Hospital, Kolkata were included in the study. A detailed history, a thorough laboratory investigation and clinical examination in respect of different organ involvement was evaluated for each visit. Result: In this study, mean age and median of study population was 23.75 and 23 years. Only 3 patients were male whereas 57 were females, with female to male ratio of 5:95. Around 88.3% presented with constitutional symptoms, with fever. Musculoskeletal symptoms were present in 41.66%. Renal system involvement was seen in 23.3% patients of which, 31.7% patients had shortness of breath at presentation and 30% had associated edema. Conclusion: The study findings showed significantly higher number of cases in females of child bearing age with constitutional symptoms and musculoskeletal involvement, followed by mucocutaneous and renal involvement.

Keywords: Clinical profile, Musculoskeletal symptoms, Systemic Lupus Erythematosus.