FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLET OF LORNOXICAM

Asim Pasha* and C. N. Somashekhar

ABSTRACT

The goal of this study was to create Lornoxicam sustained release matrix tablets in order to produce the medicine in a long-lasting form. So as to prolong its elimination time for the effective treatment of rheumatoid arthritis, and also in the management of ankylosing spondylitis, acute sciatica and low back pain. The existing examination demonstrates that use of hydrophilic and hydrophobic polymers may be successfully working for formulating sustained release matrix tablets of Lornoxicam. Optimized formulation containing HPMC K15M and xanthan gum at best ratio had successfully sustained the drug release for 24 h. Matrix tablets of optimized batch had in vitro drug release. As a result, Lornoxicam sustained release matrix tablets are effective. Biocompatible polymers were tested, analysed, and determined to be good candidates for extending the drug's release from matrix tablets.

Keywords: Lornoxicam, HPMC, Sustained release, Matrix tablets.