FORMULATION AND EVALUATION OF LULICONAZOLE SOLID DISPERSION INCORPORATED GELS

Shivani Rajesh Pawar*, Dr. D. V. Derle and Sandeep Khatale

ABSTRACT

Drug Luliconazole is a topical antifungal drug used for fungal infection treatment. Luliconazole is a novel topical antifungal imidazole with broad spectrum and potent antifungal activity. The purpose of the present research was to formulate Luliconazole solid dispersion incorporated gels. Solid dispersion was prepared in various ratios using each carrier. Solubility study and dissolution study showed that as the concentration of the carrier increase, the solubility and dissolution rate of Luliconazole increases. The particle size and surface morphology of solid dispersion were studied by SEM. IR studies showed that no chemical reaction was taken place between drug and excipient in solid dispersion.

Keywords: Solid Dispersion, Luliconazole, Carrier, Solubility, Dissolution.