MUCOADHESIVE BUCCAL DRUG DELIVERY SYSTEMS: A REVIEW

Vikash Dahiya, Dr. Saroj Jain, Dr. Seema Rohilla*

ABSTRACT

Owing to the ease of administration, the oral route is an attractive site for drug liberation. The oral route is helpful to produce mucosal (by achieving a site-specific release of drug on mucosa) and transmucosal drug administration (by absorbing drug through mucosal barrier to reach in systemic circulation). The limited absorption area and barrier properties of mucosa are main obstacles of buccal route. This article highlighted the anatomical structure of oral mucosa, advantages and limitations of buccal drug delivery, mechanisms of drug permeation through oral mucosa and formulation consideration for buccal drug delivery system.

Keywords: Transmucosal, Buccal drug delivery, Obstacles, Site-specific, Permeation, Oral mucosa.