LYMPH NODE HISTIOCYTIC SARCOMA; A RARE DISEASE, ABOUT A CASE

Khaoula Lakloumi*, Mohamed El. Fadli and Rhizlane Belbaraka

ABSTRACT

Histiocytic Sarcoma (HS) presents as an extremely rare malignant tumor, which arises from the proliferation of phagocytic cells and histiocytes. However, the literature reports a few hundred cases. HS is diagnosed based on morphology and immunohistochemistry. It often presents at an advanced clinical stage, with limited response to chemotherapy and a high death rate. In this work we report the observation of a 33-year-old patient, occasional smoker, who presented with bilateral cervical lymphadenopathy. On clinical examination, there was an enormous left laterocervical lymph node magma; with left fluid effusion syndrome on pleuropulmonary examination. The anatomo-pathological study completed by immunolabeling was compatible with lymph node histiocytic sarcoma. The patient received COP-type palliative chemotherapy (cyclophosphamide, vincristine and prednisolone). There is no standard treatment for HS due to its rarity, and it usually has primary resistance to chemotherapy or relapses soon after treatment. It is important to establisha consensus of management of HS for improving the prognosis of this rare disease.

Keywords: Histiocytic sarcoma, cervical lymphadenopathy, case report.