OXCARBAZEPINE: A COMPUTATIONAL OVERVIEW WITH ITS CURRENT POTENTIAL

Shivangi Kaushal, Najmussehar, Nadeem Siddiqui*, Shagufi Nazar, M. Shahar Yar and Ozair Alam

ABSTRACT

The success of carbamazepine as a broad-spectrum anticonvulsant drug has led to its usage as a first line drug in treatment of partial and generalized tonic clonic seizures in children and adults. Due to its adverse effects on CNS and gastrointestinal, hepatic and endocrine disturbances, teratogenic effects, oxcarbazepine was developed to provide a compound chemically similar to carbamazepine which mimics its efficacy and overall safety along with improving its side-effect profile. In comparison to the parent drug, oxcarbazepine shows great reduction in hepatic microsomal enzyme induction as well as in autoinduction. This article gives an insight into various computed and physicochemical properties of oxcarbazepine as well as provides spectral information and predictions to support its structure.

Keywords: Epilepsy, Anticonvulsant, seizures, Spectral information, Oxcarbazepine.