NANO DRUG DELIVERY SYSTEM IN PARKINSON’S DISEASE: A REVIEW

Chetna P. Hiwase, Krishna R. Gupta*, Madhura P. Dixit and Milind J. Umekar

ABSTRACT

Parkinson‟s disease (PD) is a neurodegenerative disorder and characterized by progressive degeneration of motor functions due to loss of dopamine-releasing neurons and/or associated neuronal networks and the subsequent depletion of dopamine (DA) levels in the brain area called substantia nigra. There are huge factors that cause degeneration of neurons that leads to symptoms of Parkinson's, such as increase in oxidative stress, overexpression of α-synuclein, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) exposure, and many others. Recent advantages in nanotechnology have provided many options to bypass the various barriers associated with the therapy of CNS disorders and safely deliver drug across the BBB. The present review discussed the problems associated with drug delivery in Parkinson‟s Disease and provides an information about the recent nanotechnology solutions in Parkinson‟s. The pros and cons of various novel approaches like biosensors, gene therapy, antioxidants to mention a few have been discussed with the central focus as nano drug delivery system.

Keywords: The present review discussed the problems associated with drug delivery in Parkinson?s Disease and provides an information about the recent nanotechnology solutions in Parkinson?s.