FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF LORNOXICAM USING NATURAL AND SYNTHETIC POLYMERS

Arpitha G.*, Nagesh D. R. and B. Gopalakrishna

ABSTRACT

The objective of the present work is to design of sustained release matrix tablets of Lornoxicam influence of natural and synthetic polymers on the release rate and in vitro evaluation.Lornoxicam is widely used member of non-steroidal anti inflammatory and analgesic drug with short biological half- life.Lornoxicam is practically insoluble in water because of this reason it is suitable to develop sustained release matrix tablet using hydrophilic polymers. The natural polymers like Aloe barbadensis miller leaf mucilage, Hibiscus rosa-sinensis leaves mucilage, Ghatti gum, Isabgol husk mucilage and synthetic polymers. Lactose were utilized in the formulation of matrix tablets containing Lornoxicam by wet granulation technique and evaluated for its in-vitro drug release. Granules were prepared and evaluated for loose bulk density, tapped bulk density, compressibility index and angle of repose, shows satisfactory results. Formulation was optimized on the basis of acceptable tablet properties (hardness, thickness, friability, drug content and weight variations), in vitro drug release and stability studies.

Keywords: Lornoxicam, SRDF, Controlled Release, Diffussion, Polymers.