ANTICANCER AND ANTIOXIDANT ACTIVITY OF PISCIDINOL-N, APOTIRUCALLANE TRITERPENE DERIVED FROM THE LEAVES OF WALSURA TRIFOLIATA

P. Poorna, K. Rama Krishna*, Madhu Joshi, M. Suri Appa Rao and Ch. Venkataramaiah

ABSTRACT

Piscidinol - N, a new apotirucallane type terpenoid, isolated from the leaves of Walsura Trifoliata along with some known compounds. The new compound structure is determined by comprehensive spectroscopic (particularly 2D NMR and HRESI-Mass) investigation. On the basis of docking studies, new compound was screened for its antioxidant and anticancer activities. The docking study results of novel compound bioassay studies have shown higher binding affinity for the selected activities.

Keywords: Walsura trifoliata, Piscidinol N, Anticancer activity, Antioxidant activity.