STUDY OF ACUTE BLOOD TRANSFUSION REACTIONS IN PATIENTS OF BETA THALASSEMIA

Dr. Narahari Venkata Susmitha*, Dr. Priti Kamble, Dr. Chilukuru J. Satya Mani Deepika, Dr. Suhas Kulkarni and Dr. Anil B. Kurane

ABSTRACT

Background: The thalassemias are the most common genetic disorder on a worldwide basis.[2] Early and regular blood transfusion decreases the complications of severe anemia and prolongs survival. Adverse events which occur in association with the transfusion of blood products are commonly called transfusion reactions.[1] Material and Methods: This cross-sectional study included 54 beta(β) thalassemia patients whose age ranged between 1yr to 20 years. Pre transfusion hemoglobin assessment was done for all patients. Acute blood transfusion reactions were noted in details. Results: Most common transfusion reaction was fever. By fisher exact test, significant association was observed between pre transfusion Hemoglobin level and reaction. It is observed that % of reaction was more(22%) in patients with HB level <7.5, than in patients with HB level >7.5 (6%), which was statistically significant(P value< 0.0001). Conclusion: Acute Febrile non haemolytic reactions were common among patients with low pre- transfusion hemoglobin and Fever was the most common transfusion reaction noted.

Keywords: ?-thalassemia, blood transfusion, transfusion reactions, pre- transfusion haemoglobin.