FORMULATION AND EVAUATION OF SUSTAINED RELEASE MATRIX TABLET OF IBUPROFEN

Rajesh H. J., Anu P. A., Shashikiran Y. H. and Priyanka Raj G.*

ABSTRACT

The present work was focused to formulate and evaluate sustained release matrix tablets of ibuprofen. Sustained release matrix tablets of ibuprofen was prepared by using different concentration of hydroxypropyl methyl cellulose and ethyl cellulose are matrix polymers. Ibuprofen was slightly soluble drug. Sustained release matrix tablets was prepared by wet granulation method in different polymer concentration ratio. Preformulation studies have been performed for the active pharmaceutical ingredients. Tablets have been prepared in four different formulation(F1-F4) with change in the concentration of polymers. These tablets are evaluated for various parameters weight variation test, hardness, thickness, in- vitro dissolution studies. Higher level of polymer concentration formulation(F3) shows good in vitro drug release was 96% and all the evaluation parameters are takes place within the limit.

Keywords: Ibuprofen, matrix tablets, polymers, sustained release.