FORMULATION AND EVALUATION OF LIQUISOLID COMPACTS OF ETODOLAC

P. Hyma, B. Apoorva* and E. Keerthana

ABSTRACT

In the present study, liquisolid compact technique is analyzed as a tool for enhanced dissolution of poorly water-soluble drug Etodolac. Etodolac is a pyranocarboxlyic acid and NSAID with anti-pyretic and anti-analgesic activities. Etodolac liquisolid compact formulations (6) were prepared by using Polyethylene glycol 400, Propylene glycol as solvents, microcrystalline cellulose, and hydroxypropyl methyl cellulose as carrier materials and aerosol as a coating material in different ratios. The prepared liquisolid compacts were evaluated for their pre-compression properties and out of 6 formulations F5 formulation was taken as optimized formulation based on fast dissolving property. The optimized formulation was punched into tablets by adding the excipients and the tablets were assigned for post-compression properties, drug-excipient interactions by Fourier Transform Infrared spectra (FTIR), X-Ray Diffraction (XRD). Liquisolid compacts containing Propylene Glycol (PG) as solvent produced higher dissolution rates in comparison with Polyethylene Glycol (PEG) of the same concentration. As liquisolid compacts illustrated significantly higher drug release rates, we conclude that it could be a promising favorable strategy in improving the dissolution of poorly water-soluble drugs.

Keywords: Etodolac, NSAID, liquisolid compacts, carrier material, drug-excipient interactions.